ABSTRACT
Introduction: The coronavirus infections ( disease) (COVID-19) pandemic 2019 caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) began in December 2019 and has affected millions of lives worldwide, even though many aspects of the disease are still unknown.Current data shows that many hospitalized patients with COVID-19 suffer from kidney damage manifesting as proteinuria, hematuria, or acute kidney injury (AKI). AKI is especially common among severely and critically ill patients with COVID-19 and may be a predictor of mortality.The pathophysiology of AKI associated with COVID-19 may be due to non-specific mechanisms, but also to mechanisms specific to COVID. Evaluation of morphological changes in the kidneys and their mechanisms could help determine their spectrum and immediate or long-term effects. The aim of our study was to compare the initial clinical and laboratory data of patients with COVID 19 who developed AKI and to analyze the morphological changes in the kidneys that underwent autopsy when patients died of COVID 19 with AKI. Method(s): We conducted a preliminary retrospective analysis of cured patients with COVID 19 and AKI during the pandemic period of July 2021 - December 2021. We analyzed the clinical and laboratory parameters of 2 groups of patients: thise who survived and thise who died of AKI caused by COVID 19. We also studied he main frequently detected morphological changes in the renal biopsy: the subject ground was a dead group. Statistical processing of the obtained data was performed using the STATA program. The two groups were compared, and the statistical significance of the scores of the two groups was calculated using the Mann Whitney analysis and the chi-quadrant Results: According to the results of analyzes of clinical and laboratory parameters, it can be summarized that in the group of the dead in 80% of patients, the volume of lung damage is more than the deceased than the survivors. There is a deep lymphopenia and thrombinemia in the group of the dead. The level of azotemia also prevails in the group of the deceasedAccording to our studies, out of 10 lethal cases, 90% of the histology of samples taken from the kidneys of those who died from COVID 19 revealed the following changes: edema and plethora of renal glomeruli, atrophy and sclerosis from 10-50% of the glomeruli. In the tubules, total necrosis of the epithelium. In the stroma, vascular thrombosis, focal sclerosis with lymphoid infiltration, small focal hemorrhages [Formula presented] Conclusion(s): Acute kidney injury remains a fairly common and serious manifestation of the severe course of COVID 19. Regardless of the type of development of the mechanism, it is often associated with high mortality. Our results of the study can serve as a subject for further research. No conflict of interestCopyright © 2023